Ludovica Marinelli is a PostDoctoral researcher at CMET, in the team of Prof. Tom Van de Wiele. She is also part of the international associated lab “Host Microbes Interactions in the Human Gut” (HOMIGUT https://homigut.uca.fr/), recently created between CMET and University Clermont Auvergne (France). Within HOMIGUT, she is co-leading the research axis “Small intestine microbiome in diseases” aiming at investigating the complex relationships between the small intestine microbiome and various pathological conditions (e.g., metabolic diseases, Small Intestinal Bacterial Overgrowth -SIBO-, Short Bowel Syndrome -SBS-, Chronic intestinal pseudo-obstruction -CIPO-) along with uncovering the mechanisms of host-bacteria interaction in health and disease conditions.
She is participating in the CA23110 INFOGUT COST action (https://infogut.eu/about/) focusing on the harmonization, optimization and dissemination of in vitro models simulating human or animal intestinal microbiota and ecology and she acts as leader of Task 2.2. “Coupling in vitro models with host cells”, within Working Group 2. She is also an active member of the Ghent Gut Inflammation Group (GGIG – https://www.ggig.be/) and the French Club d’Étude des cellules Épithélials Digestives (CECED- https://ceced.fr/).
Dr. Marinelli was awarded her PhD from Sorbonne University (France) on “Physiology, physiopathology and therapeutics” and a Marie-Skłodowska Curie fellowship Individual postdoctoral fellowship in 2022 for her project on the characterization of microbial and cellular signatures for Short Bowel Syndrome.
Her multidisciplinary research is oriented toward the characterization of cellular mechanisms involved in host-microbiota interaction, through the development and application of in vitro models simulating both the ecology and epithelia of human small intestine and colon. In particular, her current research lines focus on the investigating the small intestinal host-bacteria crosstalk in health and disease conditions.
Selected publications
- Delbaere K, Roegiers I, Bron A, Durif C, Van de Wiele T, Blanquet-Diot S, Marinelli L. The small intestine: dining table of host-microbiota meetings. FEMS Microbiology Review, 2023, doi: 10.1093/femsre/fuad022.
- Delbaere K, Marinelli L, De Paepe K, De Boever E, Smet Ma, Wellekens J, Hindryckx P, Van de Wiele T. (in revision). An oral biofilm reactor for long-term and large-scale human oral bacterial cultivation. Microbiology Spectrum
- Deschamps C, Tronel A, Bailly E, Sohnagou Tanfede MR, Gilbert S, Denis S, Soranzo T, Van de Wiele T, Marinelli L, Blanquet-Diot S. (in revision) Small intestinal microbiome, the underrated maestro of SIMO disease. FEMS Microbiology Review.
- Lashermes A, Mathieu E, Marinelli L, Léjard V, Dervyn E, Jules M, Lapaque N, Doré J, Multon MC, Maren Greifenberg D, Plomer M, Righetto Z, Perez M, Blottière HM. Deciphering the Mechanisms of Action Underlying Probiotic Properties of Shouchella clausii by a Functional Genomics Approach. Benef Microb, 2025, doi: 10.1163/18762891-bja00050.
- Martin-Gallausiaux C, Salesse L, Garcia-Weber D, Marinelli L, Beguet-Crespel F, Brochard V, Le Gléau C, Jamet A, Doré J, Blottière HM, Arrieumerlou C, Lapaque N. Fusobacterium nucleatum promotes inflammatory and anti-apoptotic responses in colorectal cancer cells via ADP-heptose release and ALPK1/TIFA axis activation. Gut Microbes, 2024, doi: 10.1080/19490976.2023.2295384.
- Martin-Gallausiaux C*, Marinelli L*, Blottière HM, Larraufie P, Lapaque N. SCFA: Mechanisms and Functional Importance in the Gut. Proc Nutr Soc, 2020, doi: 10.1017/S0029665120006916. *These authors contributed equally.
- Marinelli L, Martin-Gallausiaux C, Bourhis J-M, Béguet-Crespel F, Blottière HM, Lapaque N. Identification of the novel role of butyrate as AhR ligand in human intestinal epithelial cells. Sci Rep, 2019. doi: 10.1038/s41598-018-37019-2