Dr. ir. Rosemarie De Weirdt

Telephone number: 
+32 9/264 59 76
Position: 
Postdoctoral staff
Biography: 

Degree  

  • Ph.D in Life Sciences and Medicine, 2013, Ghent University, Belgium. Thesis: “Dietary fat and the human gut microbiome”
  • Bioscience Engineer, 2008, Ghent University, Belgium. Master thesis: “Anaerobic metabolism of glycerol by the colon microbiota”, honoured with the Alpro Foundation Award for Masters 2008

Guest researcher

  • April-July 2011: Center of Infectious Diseases and Vaccinology, The Biodesign Institute, Arizona State University, USA (Prof. C.A. Nickerson).
  • May 2009: Laboratory for Food Biotechnology, Swiss Federal Institute of Technology (ETH), Zürich, Switzerland (Prof. C. Lacroix)

Current research activities

  • The effect of oxygen and biomechanical stress on mucosal microbial behaviour and host responses in the gastrointestinal tract. Concerted Research Action (GOA) of the Flemish Community (BOF12/GOA/008).
  • In-house LabMET projects involving (modelling of) host-microbe interactions at the gastrointestinal mucosal interface in health and disease.
Selected key publications: 
De Weirdt R, Hernandez-Sanabria E, Fievez V, Mees E, Geirnaert A, Van Herreweghen F, Vilchez-Vargas R, Van den Abbeele P, Jauregui R, Pieper DH Vlaeminck B and Van de Wiele T. Mucosa-associated biohydrogenating microbes protect the simulated colon microbiome from stress by high fat concentrations. Environmental Microbiology in press
De Weirdt R and Van de Wiele T (2015). Micromanagement in the gut: microenvironmental factors govern colon mucosal biofilm structure and functionality. NPJ Biofilms and Microbiomes 1: 15026.
De Weirdt R, Coenen E, Vlaeminck B, Fievez V, Van den Abbeele P and Van de Wiele T (2013). A simulated mucus layer protects Lactobacillus reuteri from the inhibitory effects of linoleic acid. Beneficial Microbes 4: 299-312.
De Weirdt R, Crabbé A, Roos S, Vollenweider S, Lacroix C, van Pijkeren JP, Britton RA, Sarker S, Van de Wiele T and Nickerson CA (2012). Glycerol supplementation enhances Lactobacillus reuteri’s protective effect against Salmonella Typhimurium colonization in a 3-D model of colonic epithelium. Plos One 7: e37116.
De Weirdt R, Possemiers S, Vermeulen G, Moerdijk-Poortvliet TCW, Boschker HTS, Verstraete W and Van de Wiele T (2010). Human faecal microbiota display variable patterns of glycerol metabolism. FEMS Microbiology Ecology 74: 601-611.